MicroRNA-340-5p modulates cisplatin resistance by targeting LPAATβ in osteosarcoma
نویسندگان
چکیده
منابع مشابه
MicroRNA-340-5p modulates cisplatin resistance by targeting LPAATβ in osteosarcoma
MicroRNAs (miRNAs) play an important role in drug resistance and modulate the efficiency of chemotherapy. A recent study indicated that miR-340 functions as a tumor suppressor in various types of cancer. However, the role of miR-340 in chemotherapy has not been reported yet. In this study, we found that miR-340 enhanced cisplatin (CDDP)-induced cell death. Induction of miR-340-5p expression dec...
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Osteosarcoma (OS) is the most common cancer of the bone. Chemotherapy is commonly used for the clinical treatment of OS. However, chemoresistance to cisplatin [also known as diamminedichloridoplatinum (II) (DDP)] is a major obstacle for OS therapy, the underlying mechanism of which is not fully understood. The present study aimed to investigate the role of microRNA (miR)-199a-5p in the regulati...
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BACKGROUND Early metastasis of osteosarcoma (OS) is highly lethal and responds poorly to drug and radiation therapies. MicroRNAs (miRNAs) are a class of small noncoding RNAs that modulate gene expression at the post-transcriptional level. However, the detailed functions of specific miRNAs are not entirely understood. The aim of the present study was to investigate the role of miR-184 as a media...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 2017
ISSN: 1414-431X,0100-879X
DOI: 10.1590/1414-431x20176359